split   thread.
  sir have outlook 2016 latest update 15.39, os x sierra 10.12.6 (an hour ago on el capitan, updated try solve issue) , reason, messages, reply/reply all/forward buttons no work @ all. note   messages, not all.
                       
                hi jean,
   
  thanks post. "button" issue, suggest try following steps see if issue can fixed:
   
    - reinstall safari: safari browser installed on computer. if browser not working correctly, outlook not function. therefore, need reinstall browser. can reinstall safari browser on own if reason can't,   contact apple support.
 - if have cisco webex plugin installed, please upgrade webex productivity tools latest version. , can try disable webex plug-in see whether issue happen.
 - about these buttons not work, did these buttons grayed out? or there no response after click it? please provide more information , screenshots if possible.
 - which kind of message have issue? point difference between problematic message , normal message?
 
   
  meanwhile, have dedicated support channel outlook mac issues. can contact them outlook mac issues , getting better support (go > contact support). , if have updates it, can share in our   community.
   
  regards,
  richard
             
                Office                /                        Outlook                    /                        Mac                    /                        Office 365 for business                
 
  
 
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